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KMID : 1150320200160010007
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Journal of Korean Society of Geriatric Neurosurgery
2020 Volume.16 No. 1 p.7 ~ p.11
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Risk Factor of Cerebral aneurysm and Correlation with Vitamin D Deficiency
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Chung Yong-Jun
Kim Hak-Sung
Jang Suk-Jung
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Abstract
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Objective: The purpose of this study is to prove that vitamin D supplementation can prevent aneurysm rupture in patients with unruptured aneurysms.
Methods: We reviewed medical record of 60 patients who were diagnosed as having cerebral aneurysm(ruptured or unruptured) among the patients and had vitamin D test. 60 patients who had no aneurysms were retrospectively analyzed as a control group. 60 patients with a diagnosis of aneurysm were divided into subgroups of subarachnoid hemorrhage due to ruptured cerebral aneurysm. Other risk factors such as age, sex, hypertension, diabetes, coronary artery disease, hyperlipidemia, drinking, smoking, body mass index, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were compared with vitamin D levels.
Results: In a total of 120 patients, vitamin D deficiency was confirmed in the majority of the subjects (12.74 ng/mL in the experimental group and 19.49 ng/mL in the control group). In the group of 60 patients with cerebral aneurysms, hypertension (p<0.047), Smoking (p<0.01), vitamin D deficiency (p<0.001) and CRP (p<0.025) were significant risk factors.
Conclusion: In patients with a cerebral aneurysm, vitamin D deficiency was significantly higher than in patients without cerebral aneurysms, suggesting that vitamin D supplementation may play a protective role in the development and rupture of the aneurysm.
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KEYWORD
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Vitamin D deficiency, Intracranial aneurysm, Risk factors of intracranial aneurysm, Vitamin D
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